Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives

Immune Escape Mechanisms in Colorectal Cancer Pathogenesis and Liver Metastasis

Over the past decade, growing evidence indicates that the tumor microenvironment (TME) contributes with genomic/epigenomic aberrations of malignant cells to enhance cancer cells survival, invasion, and dissemination. Many factors, produced or de novo synthesized by immune, stromal, or malignant cells, acting in a paracrine and autocrine fashion, remodel TME and the adaptive immune response culm...

Experimental Colorectal Cancer Liver Metastasis

Liver metastasis from colorectal cancer 12 years after liver transplantation.

Liver transplantation is an effective treatment for many liver diseases, with a 5-year survival of about 70 %. However, development of de novo malignancies in these immunocompromised patients is becoming a frequent complication medium term. The annual risk of developing a malignant tumor after a solid organ transplant is 2% . We report the case of a liver transplant patient who developed colore...

[Outcome of surgical treatment of liver metastasis from colorectal cancer].

BACKGROUND Surgical resection is the only treatment associated with long-term cure in patients with liver metastasis from colorectal cancer, achieving a 30% to 40% five years survival. AIM To evaluate the results of liver resection for metastatic colorectal cancer in our centre. PATIENTS AND METHODS Retrospective study. Epidemiological, perioperative and follow up data of patients undergoin...

[Treatment strategy for synchronous liver metastasis from colorectal cancer].

BACKGROUND & OBJECTIVE The patients with synchronous liver metastasis from colorectal cancer might get long-term survival after liver resection. But the optimal timing of surgery is undefined. This study was to explore the treatment strategy for synchronous liver metastasis from colorectal cancer. METHODS From 1995 to 2005, 83 patients with synchronous liver metastasis from colorectal cancer ...